Researchers at the Icahn School of Medicine at Mount Sinai have characterized how cellular senescence—a biological process in which aging cells change how they function—is associated with human brain ...

Mount Sinai and BPGbio scientists uncover novel molecular drivers from live brain samples that direct human brain structure and function from ...

Aging cells secrete substances known to promote the growth of cancer cells. The development of drugs that can selectively kill these cells or inhibit the secretion of substances is ongoing. The latest ...

T cell senescence occurs in the TME, affecting cancer prognosis and immunotherapy efficacy. The TME induces T cell senescence through multiple pathways, including persistent stimulation by ...

The latest findings on the interaction between cell death and cellular senescence in cancer and their pathophysiological significance have been reviewed. Aging cells secrete substances known to ...

Cellular senescence—an irreversible cell-cycle arrest coupled with the production of pro-inflammatory secretions known as SASP—is now viewed as a central driver of musculoskeletal aging. Accumulation ...

T cell senescence occurs in the TME, affecting cancer prognosis and immunotherapy efficacy. The TME induces T cell senescence through multiple pathways, including persistent stimulation by ...

Senescence is a process in which a cell ages and stops dividing but does not die. In keratinocytes, or skin cells, senescence is marked by depolarization of membrane potential (Vmem), the electrical ...

As time marches on, aging is inevitable. Naturally, a person can accumulate wrinkles, laugh lines, stress, and cellular damage. Of these, damaged cells can take multiple paths: they can undergo ...