1 in 4 Indian breast cancer patients carry inherited genetic risk variants, outside known genes: study

A study reveals 1 in 4 Indian breast cancer patients carry inherited genetic variants beyond known BRCA genes, urging broader testing strategies.
MedPage Today

In Newly Diagnosed Prostate Cancer, Detecting Variants in Homologous Recombination Repair Genes

Identification of variants influences treatment decisions. Inhibitors of the poly-ADP-ribose polymerase (PARP) system, a pathway for repairing single-stranded DNA breaks, are recommended for tumors ...
ascopubs.org

Phase II Study of Niraparib in Patients With Advanced Melanoma With Homologous Recombination Pathway Gene Mutations

Fourteen patients were accrued to the trial, which was discontinued because of slow accrual. The median age was 71 years. Nine patients had an Eastern Cooperative Oncology Group performance status of ...
ascopubs.org

Detection of mutations in homologous recombination repair (HRR) pathway genes using liquid biopsy in metastatic, castration-resistant prostate cancer (mCRPC) patients without ...

Real world outcomes of 177Lu-PSMA-617 PSMA in a racially diverse cohort of patients with metastatic castration resistant prostate cancer (mCRPC). This is an ASCO Meeting Abstract from the 2025 ASCO ...