Among modern cancer therapies, immune checkpoint inhibitors (ICI) are among the most successful treatment methods. These ...

Brain tissue analysis of an animal model has revealed the potential role of immune system dysfunction in the onset and progression of Alzheimer's disease (AD). Published April 15, 2025 in the Journal ...

Eighty percent of patients with autoimmune diseases are female. These diseases are one of the top 10 leading causes of death for women under 65, and cases are increasing annually worldwide. There is ...

Neurodegenerative diseases, traditionally viewed as driven by neuronal decline, are increasingly recognized to involve ...

The immune system’s capacity to distinguish self from non-self is in large part mediated by immunoglobulins, with IgG playing a pivotal role in both protective and pathological responses.

T cells represent a central component of the adaptive immune system, orchestrating responses that protect against pathogens while maintaining tolerance towards self-antigens. Their dysregulation, ...

Engineered antigen-presenting extracellular vesicles (AP-EVs) deliver peptide-MHCII, IL-2, and TGF-β to naïve antigen-specific CD4⁺ T cells, driving their differentiation into Foxp3⁺ regulatory T ...

There are at least 70 documented autoimmune diseases [36] and the prevalence of autoimmune disease is rapidly rising worldwide, for reasons not completely understood. [37] Although the disorders share ...

A single large population of healer cells, called regulatory T cells, is whizzing around our body -- not multiple specialist populations restricted to specific parts of the body as previously thought.

A novel tumor suppressor, BATF2, can be silenced by factors in the tumor microenvironment, leading to a reduced immune ...

Urological malignancies, including prostate, bladder, renal, and testicular cancers, represent a major global health burden and display remarkable ...