The complement component 1q (or simply C1q) is a protein complex involved in the complement system, which is part of the innate immune system. C1q together with C1r and C1s form the C1 …

C1q, historically viewed as the initiating component of the classical complement pathway, also exhibits a variety of complement-independent activities in both innate and acquired immunity.

Apr 29, 2025 · C1q is a multimeric protein that serves as the recognition unit of the C1 complex, the first component of the classical complement pathway. It consists of six heterotrimeric subunits, each …

Dec 1, 2021 · In this review, we provide a comprehensive overview of the current literature on circulating levels of C1q in health and disease, and discuss how C1q can both protect against infections as well …

Jun 29, 2015 · Complement protein C1q, the recognition subcomponent of the classical pathway, performs a diverse range of complement and non-complement functions. It can bi...

C1q is a multifunctional protein with complement-dependent and independent roles that span immune defense, tissue homeostasis, and disease modulation. Its diverse functions are underpinned by its …

Human C1q is the first recognition molecule of the classical pathway of the complement system. C1q has a characteristic tulip-like overall structure where N-terminal collagenous stalk (CLR) is followed …

C1q, an evolutionarily ancient protein canonically known as the initiator of the classical complement pathway, is increasingly appreciated to have a variety of complement-independent functions in...

Jul 24, 2025 · C1q serves as the initial trigger for the classical pathway of the complement system, a defense against pathogens. It operates as part of a larger molecular assembly known as the C1 …

Aug 5, 2025 · C1q is best known as the recognition subcomponent of the classical complement pathway. Together with C1r and C1s, it forms the C1 complex, which is activated upon binding to …