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What is more effective: vaginal estrogen cream or suppositories? We do not have head to head trials, but here is what we do know. . Creams can cover more surface area and many women like that they can rub a little on the external tissues, but they can be a bit messy. Suppositories are less messy and easy to insert, but they do not absorb as well when they sit too far back, so they are usually best for mild dryness. . To be honest, the best option is the one you will actually use. . Check out joi
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